We could find no record of St John's Wort interacting with ibuprofen. We used the Medscape drug interaction checker (1), the RPSGB 'Herb-medicine interactions: St John's wort (Hypericum perforatum)' (2) and the 2004 BMJ article 'Interaction of St John's wort with conventional drugs: systematic review of clinical trials' (3) A search of Medline found one related article (4) 'Effects of St.